Structure of PDB 7af1 Chain A Binding Site BS03

Receptor Information
>7af1 Chain A (length=358) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLE
CSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDESGEK
EEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSG
GRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVW
LNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQI
HACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNV
IVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVE
ILKPLCRS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7af1 Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7af1 Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		D37 H38 D136
Binding residue
(residue number reindexed from 1)		D35 H36 D133
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
External links
PDB RCSB:7af1, PDBe:7af1, PDBj:7af1
PDBsum7af1
PubMed34387696
UniProtQ96SD1|DCR1C_HUMAN Protein artemis (Gene Name=DCLRE1C)

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