Structure of PDB 7a3x Chain A Binding Site BS03

Receptor Information
>7a3x Chain A (length=360) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAAVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMS
KQSEEGVTFHMLSPERSIEIQHLLGSDIVMAFDESTPYPATPSRAASSME
RSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGF
DGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVE
RGIDMFDSVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVC
QKWSRACIHALIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQF
AQDFRARYFA
Ligand information
Ligand IDQXB
InChIInChI=1S/C4H8O2S/c5-7(6)3-1-2-4-7/h1-4H2
InChIKeyHXJUTPCZVOIRIF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O=[S]1(=O)CCCC1
OpenEye OEToolkits 2.0.7C1CCS(=O)(=O)C1
FormulaC4 H8 O2 S
Namesulfolane;
thiolane 1,1-dioxide
ChEMBLCHEMBL3186899
DrugBank
ZINCZINC000003860777
PDB chain7a3x Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7a3x Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		V45 L54 I351
Binding residue
(residue number reindexed from 1)		V36 L44 I328
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a3x, PDBe:7a3x, PDBj:7a3x
PDBsum7a3x
PubMed34081441
UniProtP28720|TGT_ZYMMO Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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