Structure of PDB 7a0b Chain A Binding Site BS03

Receptor Information
>7a0b Chain A (length=375) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMS
LSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDESTPY
PATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLR
QQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMG
VGKPDDIVGAVERGIDMFDSVLPTRSGRNGQAFTWDGPINIRNARFSEDL
KPLDSECHCAVCQKWSRACIHALIRAGEILGAMLMTEHNIAFYQQLMQKI
RDSISEGRFSQFAQDFRARYFARNS
Ligand information
Ligand IDQTQ
InChIInChI=1S/C4H8O4S/c5-3-1-9(7,8)2-4(3)6/h3-6H,1-2H2/t3-,4-/m0/s1
InChIKeyLDVDYVUZEKIBDP-IMJSIDKUSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O[C@H]1C[S](=O)(=O)C[C@@H]1O
OpenEye OEToolkits 2.0.7C1[C@@H]([C@H](CS1(=O)=O)O)O
CACTVS 3.385O[CH]1C[S](=O)(=O)C[CH]1O
OpenEye OEToolkits 2.0.7C1C(C(CS1(=O)=O)O)O
FormulaC4 H8 O4 S
Name(3~{R},4~{R})-1,1-bis(oxidanylidene)thiolane-3,4-diol
ChEMBL
DrugBank
ZINCZINC000001083909
PDB chain7a0b Chain A Residue 407 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7a0b Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Resolution1.77 Å
Binding residue
(original residue number in PDB)		M75 A80 E81 H133
Binding residue
(residue number reindexed from 1)		M65 A70 E71 H122
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a0b, PDBe:7a0b, PDBj:7a0b
PDBsum7a0b
PubMed34081441
UniProtP28720|TGT_ZYMMO Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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