Structure of PDB 6zy8 Chain A Binding Site BS03

Receptor Information
>6zy8 Chain A (length=1159) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFV
PGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV
EHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFT
VETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKM
QSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDK
LDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDY
VADQIVTKLVDVVKKKNVKAHQVKNHMWIFVNALIENPTFDSQTKENMTL
QPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHN
RIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGV
FPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRY
GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKN
KQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKR
HRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPED
YLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC
FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNL
LQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDN
QRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGE
EPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQ
TYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERV
GLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLR
KEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYD
SDPVKAWKEAQQKVSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELD
TLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQ
MAEVLPSPR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zy8 Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Resolution7.4 Å
Binding residue
(original residue number in PDB)		K489 S497 D545 R713 K723 H759 S763 N770 E854 I856 R929
Binding residue
(residue number reindexed from 1)		K456 S464 D512 R680 K690 H726 S730 N737 E821 I823 R896
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008301 DNA binding, bending
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 DNA damage response
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0030261 chromosome condensation
GO:0030263 apoptotic chromosome condensation
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0043065 positive regulation of apoptotic process
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0060255 regulation of macromolecule metabolic process
GO:1905463 negative regulation of DNA duplex unwinding
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0032991 protein-containing complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zy8, PDBe:6zy8, PDBj:6zy8
PDBsum6zy8
PubMed34016969
UniProtP11388|TOP2A_HUMAN DNA topoisomerase 2-alpha (Gene Name=TOP2A)

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