Structure of PDB 6yxh Chain A Binding Site BS03

Receptor Information
>6yxh Chain A (length=350) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFG
AVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSC
CIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYG
MLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLR
NFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRADLEDN
WETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSP
EMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6yxh Chain A Residue 412 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6yxh An automated platform for structural analysis of membrane proteins through serial crystallography.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		E60 K114 N115
Binding residue
(residue number reindexed from 1)		E60 K114 N115
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.23: ceramidase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0009055 electron transfer activity
GO:0016787 hydrolase activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040 N-acylsphingosine amidohydrolase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006954 inflammatory response
GO:0008284 positive regulation of cell population proliferation
GO:0022900 electron transport chain
GO:0042552 myelination
GO:0043067 regulation of programmed cell death
GO:0046512 sphingosine biosynthetic process
GO:0046514 ceramide catabolic process
GO:0071602 phytosphingosine biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yxh, PDBe:6yxh, PDBj:6yxh
PDBsum6yxh
PubMed34723237
UniProtQ9NUN7|ACER3_HUMAN Alkaline ceramidase 3 (Gene Name=ACER3)

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