Structure of PDB 6yii Chain A Binding Site BS03

Receptor Information
>6yii Chain A (length=473) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKSWNHDRAAKHIDQKIADVEEITIKDYVRDMSLESIPTSTAYRVDGVH
MYADIMNLEDMLNITAVEGTECHKRTLRFLDQHYRAVKRILNKVDARRVD
FHSQRLHSLFTKPYNTESGAETKRVQRAVATAQLIIDVLAETGDDDEQIP
AAKVRIGIDTGLALAVNNGRSGYREPLFLGDPANHAAKLASNNKARGIYL
TNNARKAIGLAESDEPEKSALTAIEIKACQDAAKLDVTSDEIVEEWREDL
KKNPIGGYQFSRQTPPLRDMDIYSLTPANSKRQEMVSLYADIDGFTAYVA
DHINEKTDDVVRTLHVIRSELERVVTSDFEGRRVRFIGDCVQALSCDGTA
HTTDEEKSVSEATRLAGALRSSFNLAIERLNAEGIETGDLGLAIGFDLGP
IAVTRLGAKGNRVRCAIGRSVIESEKRQCACSGVETAIGQVAYDAASKAV
QNLFGKSRKTSHLDYNEATEALA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6yii Chain A Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6yii Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
Resolution1.44 Å
Binding residue
(original residue number in PDB)		F454 S457 K459
Binding residue
(residue number reindexed from 1)		F454 S457 K459
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.26: uridylate cyclase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yii, PDBe:6yii, PDBj:6yii
PDBsum6yii
PubMed32454240
UniProtP0DV40|PYCC_PSEAI Uridylate cyclase (Gene Name=pycC)

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