Structure of PDB 6yd5 Chain A Binding Site BS03

Receptor Information
>6yd5 Chain A (length=307) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESK
IQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGG
TGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAV
DTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVN
LDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQ
GVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVV
TVIATGF
Ligand information
Ligand IDOM8
InChIInChI=1S/C14H10ClF2NO2/c15-9-3-1-2-8(6-9)7-20-11-5-4-10(16)12(13(11)17)14(18)19/h1-6H,7H2,(H2,18,19)
InChIKeyQPJFTLSXPCJEKL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc(cc(c1)Cl)COc2ccc(c(c2F)C(=O)N)F
CACTVS 3.385NC(=O)c1c(F)ccc(OCc2cccc(Cl)c2)c1F
FormulaC14 H10 Cl F2 N O2
Name3-[(3-chlorophenyl)methoxy]-2,6-bis(fluoranyl)benzamide
ChEMBLCHEMBL5092442
DrugBank
ZINC
PDB chain6yd5 Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6yd5 Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		G196 D199 L200 V203 N208 L209 L261 N263 V297 T309 V310 I311
Binding residue
(residue number reindexed from 1)		G188 D191 L192 V195 N200 L201 L253 N255 V289 T301 V302 I303
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6yd5, PDBe:6yd5, PDBj:6yd5
PDBsum6yd5
PubMed33908781
UniProtQ2FZ89|FTSZ_STAA8 Cell division protein FtsZ (Gene Name=ftsZ)

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