Structure of PDB 6ya8 Chain A Binding Site BS03

Receptor Information

>6ya8 Chain A (length=340) Species: 9606 (Homo sapiens)

AGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKI
ALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYL
EHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNR
RLKKYALVDFGLAQGTHDTKIELLKFVPASLTCDCYATDKVCSICLSRRQ
QVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS
DDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGA
GGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM

Ligand information

• Ligand ID: BEF
• InChI: InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
• InChIKey: OGIAHMCCNXDTIE-UHFFFAOYSA-K
• SMILES:
  OpenEye OEToolkits 1.5.0: [Be-](F)(F)F
  ACDLabs 10.04
  CACTVS 3.341: F[Be-](F)F
• Formula: Be F3
• Name: BERYLLIUM TRIFLUORIDE ION
• PDB chain: 6ya8 Chain A Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ya8 Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
• Resolution: 1.79 Å
• Binding residue (original residue number in PDB): D177 K179 N182 D196
• Binding residue (residue number reindexed from 1): D140 K142 N145 D159
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D177 K179 N182 D196 T376
• Catalytic site (residue number reindexed from 1): D140 K142 N145 D159 T208
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6ya8, PDBe:6ya8, PDBj:6ya8
• PDBsum: 6ya8
• PubMed: 32521228
• UniProt: O00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)