Structure of PDB 6ya7 Chain A Binding Site BS03

Receptor Information

>6ya7 Chain A (length=350) Species: 9606 (Homo sapiens)

GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIA
LKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLE
HESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR
LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERPASLTCDCYATDKVCS
ICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGR
YPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKL
CERLRGAGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6ya7 Chain A Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ya7 Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
• Resolution: 1.67 Å
• Binding residue (original residue number in PDB): N182 D196
• Binding residue (residue number reindexed from 1): N144 D158
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D177 K179 N182 D196 T376
• Catalytic site (residue number reindexed from 1): D139 K141 N144 D158 T215
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6ya7, PDBe:6ya7, PDBj:6ya7
• PDBsum: 6ya7
• PubMed: 32521228
• UniProt: O00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)