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Receptor Information

>6wc0 Chain A (length=938) Species: 351607 (Acidothermus cellulolyticus 11B) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERS
GASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDA
WLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQ
PSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSLSN
ATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAER
IGRDPLDPSQLRASRACLEFQEYRIVAAVANLRIRDGSGSRPLSLEERNA
VIEALLAQTERSLTWSDIALEILKLPNESDLTSVPEEDGPSSLAYSQFAP
FDETSARIAEFIAKNRRKIPTFAQWWQEQDRTSRSDLVAALADNSIAGHL
PDAELEALEGLALPSGRVAYSRLTLSGLTRVMRDDGVDVHNARKTCFGVD
DNWRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVELGSA
GGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAEARRWLDISIERLFSRV
AIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKTLADARSRRVSASTEEP
QSPAYRQWKESCSGLGDLLISTAARDSIAVAAPLRLRPTGALHEETLRAF
SEHTVGAAWKGAELRRIVEPEVYAAFLALTDPGGRFLKVSPSEDVLPADE
NRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGAAYIASFHHARVFRWGSS
HSPSFALLRVSLADLAVAGLLRDGVDVFTAELPPWTPAWRYASIALVKAV
ESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSMFLKYFPERHWVVTGFED
DKRINLKPAFLSAEQAEVLRTERSDRPDTLTEAGEILAQFFPRCWRATVA
KVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPWSADPW

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6wc0 The molecular basis for recognition of 5'-NNNCC-3' PAM and its methylation state by Acidothermus cellulolyticus Cas9.
Resolution	3.61 Å
Binding residue (original residue number in PDB)	R55 R919 F934 T1041 G1042 F1043 E1044
Binding residue (residue number reindexed from 1)	R49 R724 F739 T846 G847 F848 E849

Enzyme Commision number

	Molecular Function
GO:0003676	nucleic acid binding

PDB	RCSB:6wc0, PDBe:6wc0, PDBj:6wc0
PDBsum	6wc0
PubMed	33311465
UniProt	A0LWB3

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Structure of PDB 6wc0 Chain A Binding Site BS03