Structure of PDB 6vf4 Chain A Binding Site BS03

Receptor Information

>6vf4 Chain A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVLK
ALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTM
KLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLS
TPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITH
PKEGQEAGLLPRVMCRLQDQGLILYHQFERSFCIFRLPQPGSWKAVRVDL
VVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQKTF
FQAASEEDIFRHLGLEYLPPEQRNA

Ligand information

>6vf4 Chain D (length=4) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gccg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6vf4 DNA Polymerase Mu, 8-oxorGTP:At Reaction State Ternary Complex, 50 mM Mn2+ (30 min)
Resolution	1.75 Å
Binding residue (original residue number in PDB)	G174 R175 T178 F179 H204 G206 H208 S209
Binding residue (residue number reindexed from 1)	G37 R38 T41 F42 H67 G69 H71 S72

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6vf4, PDBe:6vf4, PDBj:6vf4
PDBsum	6vf4
PubMed
UniProt	Q9NP87\|DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Gene Name=POLM)

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