Structure of PDB 6v5b Chain A Binding Site BS03

Receptor Information
>6v5b Chain A (length=908) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAK
AAVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIR
HSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHE
YIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELF
SLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLS
MHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTK
PSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYV
KLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFW
KTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMT
HPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINI
MSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLAT
YRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALI
GAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLI
ETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEF
LGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQE
YAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPR
LKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTY
TVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKY
RQELKEMR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6v5b Chain A Residue 1402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v5b Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		S539 A540 K541 A542 R543
Binding residue
(residue number reindexed from 1)		S91 A92 K93 A94 R95
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0031054 pre-miRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6v5b, PDBe:6v5b, PDBj:6v5b
PDBsum6v5b
PubMed32220646
UniProtQ9NRR4|RNC_HUMAN Ribonuclease 3 (Gene Name=DROSHA)

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