Structure of PDB 6uy0 Chain A Binding Site BS03

Receptor Information
>6uy0 Chain A (length=1210) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDPNPCPESSASFLSRITFWWITGMMVQGYRQPLESTDLWSLNKEDTSEQ
VVPVLVKNWKKECAKSPSLFKVLYKTFGPYFLMSFLFKAVHDLMMFAGPE
ILKLLINFVNDKKAPEWQGYFYTALLFISACLQTLVLHQYFHICFVSGMR
IKTAVIGAVYRKALVITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMI
WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPLNAVMAMKTKTYQVAH
MKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAY
LAAVGTFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVSLALFNILRF
PLNILPMVISSIVQASVSLKRLRVFLSHEDLDPDSIQRRPITNSITVKNA
TFTWARNDPPTLHGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVE
GHVTVKGSVAYVPQQAWIQNISLRENILFGRQLQERYYKAVVEACALLPD
LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDVYLLDDPLSAVD
AHVGKHIFENVIGPKGLLKNKTRLLVTHAISYLPQMDVIIVMSGGKISEM
GSYQELLARDGAFAEFLRTYAETWKLVEADKAQTGQVKLSVYWDYMKAIG
LFISFLSIFLFLCNHVASLVSNYWLSLWTDDPIVNGTQEHTQVRLSVYGA
LGISQGITVFGYSMAVSIGGIFASRRLHLDLLHNVLRSPISFFERTPSGN
LVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPMAAVIIPP
LGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQ
ERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFASLFAVIS
RHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE
KEAPWQIQDMAPPKDWPQVGRVEFRDYGLRYREDLDLVLKHINVTIDGGE
KVGIVGRTGAGKSSLTLGLFRIKESAEGEIIIDDINIAKIGLHDLRFKIT
IIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLNH
ECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQST
IRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEWGSPSDLLQQRGLF
YSMAKDSGLV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6uy0 Chain A Residue 1603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uy0 Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
Resolution3.23 Å
Binding residue
(original residue number in PDB)		S685 Q713
Binding residue
(residue number reindexed from 1)		S436 Q464
Annotation score1
Enzymatic activity
Enzyme Commision number 7.6.2.2: ABC-type xenobiotic transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008559 ABC-type xenobiotic transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0022857 transmembrane transporter activity
GO:0034634 glutathione transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0009410 response to xenobiotic stimulus
GO:0034775 glutathione transmembrane transport
GO:0042908 xenobiotic transport
GO:0050729 positive regulation of inflammatory response
GO:0055085 transmembrane transport
GO:0070729 cyclic nucleotide transport
GO:0071716 leukotriene transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uy0, PDBe:6uy0, PDBj:6uy0
PDBsum6uy0
PubMed32458799
UniProtQ8HXQ5|MRP1_BOVIN Multidrug resistance-associated protein 1 (Gene Name=ABCC1)

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