Structure of PDB 6uv2 Chain A Binding Site BS03

Receptor Information

>6uv2 Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVF
AFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGK
TLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCS
RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTY
LVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFL
RDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKT
IIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPI
LIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTF
FTPGNLKQARELIKVLEEANQAINPKLMQLV

Ligand information

Ligand ID

BEF

InChI

InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3

InChIKey

OGIAHMCCNXDTIE-UHFFFAOYSA-K

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	[Be-](F)(F)F
ACDLabs 10.04 CACTVS 3.341	F[Be-](F)F

Formula

Be F3

Name

BERYLLIUM TRIFLUORIDE ION

ChEMBL

DrugBank

ZINC

PDB chain

6uv2 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6uv2 RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Resolution	1.894 Å
Binding residue (original residue number in PDB)	T138 K142 R429 R432
Binding residue (residue number reindexed from 1)	T96 K100 R387 R390
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:6uv2, PDBe:6uv2, PDBj:6uv2
PDBsum	6uv2
PubMed	31851931
UniProt	Q92841\|DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (Gene Name=DDX17)

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