Structure of PDB 6usp Chain A Binding Site BS03

Receptor Information

>6usp Chain A (length=596) Species: 7070 (Tribolium castaneum)

MVHYYRLSLKSRQKAPKIVNSKYNSILNIALKNFRLCKKHKTKKPVQILA
LLQEIIPKSYFGTTTNLKRFYKVVEKILTQSSFECIHLSVLHKCYDYDAI
PWLQNVEPNLRPKLLLKHNLFLLDNIVKPIIAFYYKPIKTLNGHEIKFIR
KEEYISFESKVFHKLKKMKYLVEVQDEVKPRGVLNIIPKQDNFRAIVSIF
PDSARKPFFKLLTSKIYKVLEEKYKTSGSLYTCWSEFTQKTQGQIYGIKV
DIRDAYGNVKIPVLCKLIQSIPTHLLDSEKKNFIVDHISNQFVAFRRKIY
KWNHGLLQGDPLSGCLCELYMAFMDRLYFSNLDKDAFIHRTVDDYFFCSP
HPHKVYDFELLIKGVYQVNPTKTRTNLPTHRHPQDEIPYCGKIFNLTTRQ
VRTLYKLPPNYEIRHKFKLWNFNNQISDDNPARFLQKAMDFPFICNSFTK
FEFNTVFNDQRTVFANFYDAMICVAYKFDAAMMALRTSFLVNDFGFIWLV
LSSTVRAYASRAFKKIVTYKGGKYRKVTFQCLKSIAWRAFLAVLKRRTEI
YKGLIDRIKSREKLTMKFHDGEVDASYFCKLPEKFRFVKINRKASI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6usp Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6usp Mechanisms of nucleotide selection by telomerase.
• Resolution: 3.56 Å
• Binding residue (original residue number in PDB): D251 D343 D344
• Binding residue (residue number reindexed from 1): D251 D343 D344
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:6usp, PDBe:6usp, PDBj:6usp
• PDBsum: 6usp
• PubMed: 32501800
• UniProt: Q0QHL8