BioLiP

>6u9v Chain A (length=560) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQR
KEPLISSVHTKVKGVAEVTENVTKLVHGIFDTADYTLPLQGNSFFVMTNY
LKSEGQEQKLCPEYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQK
RKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNI
LPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFTEVAVQGGIMGIEIYW
DCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRT
LIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTY
ASTCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPH
IWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRLSRDSPDWCQCGNCLPS
QLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLA
LEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQ
GQYSGFKYPY

Software

SMILES

CACTVS 3.341

[Zn++]

ACDLabs 10.04
OpenEye OEToolkits 1.5.0

[Zn+2]

Molecular Function

GO:0000287

magnesium ion binding

GO:0001530

lipopolysaccharide binding

GO:0001614

purinergic nucleotide receptor activity

GO:0004931

extracellularly ATP-gated monoatomic cation channel activity

GO:0005102

signaling receptor binding

GO:0005216

monoatomic ion channel activity

copper ion binding

protein binding

ATP binding

zinc ion binding

channel activity

signaling receptor activity

GO:0042802

identical protein binding

GO:0043539

protein serine/threonine kinase activator activity

GO:0097110

scaffold protein binding

	Biological Process
GO:0000165	MAPK cascade
GO:0000902	cell morphogenesis
GO:0001845	phagolysosome assembly
GO:0001913	T cell mediated cytotoxicity
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002028	regulation of sodium ion transport
GO:0006509	membrane protein ectodomain proteolysis
GO:0006649	phospholipid transfer to membrane
GO:0006811	monoatomic ion transport
GO:0006812	monoatomic cation transport
GO:0006816	calcium ion transport
GO:0006884	cell volume homeostasis
GO:0006900	vesicle budding from membrane
GO:0006954	inflammatory response
GO:0007005	mitochondrion organization
GO:0007009	plasma membrane organization
GO:0007166	cell surface receptor signaling pathway
GO:0009306	protein secretion
GO:0009410	response to xenobiotic stimulus
GO:0009612	response to mechanical stimulus
GO:0009617	response to bacterium
GO:0010043	response to zinc ion
GO:0010467	gene expression
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010628	positive regulation of gene expression
GO:0012501	programmed cell death
GO:0014047	glutamate secretion
GO:0014049	positive regulation of glutamate secretion
GO:0014051	gamma-aminobutyric acid secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0016079	synaptic vesicle exocytosis
GO:0016485	protein processing
GO:0017121	plasma membrane phospholipid scrambling
GO:0019228	neuronal action potential
GO:0019233	sensory perception of pain
GO:0030163	protein catabolic process
GO:0030501	positive regulation of bone mineralization
GO:0032060	bleb assembly
GO:0032308	positive regulation of prostaglandin secretion
GO:0032310	prostaglandin secretion
GO:0032496	response to lipopolysaccharide
GO:0032730	positive regulation of interleukin-1 alpha production
GO:0032731	positive regulation of interleukin-1 beta production
GO:0032755	positive regulation of interleukin-6 production
GO:0032963	collagen metabolic process
GO:0033198	response to ATP
GO:0034220	monoatomic ion transmembrane transport
GO:0034405	response to fluid shear stress
GO:0034767	positive regulation of monoatomic ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0042098	T cell proliferation
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043132	NAD transport
GO:0043409	negative regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0045332	phospholipid translocation
GO:0045778	positive regulation of ossification
GO:0045779	negative regulation of bone resorption
GO:0045794	negative regulation of cell volume
GO:0045821	positive regulation of glycolytic process
GO:0046513	ceramide biosynthetic process
GO:0046931	pore complex assembly
GO:0048705	skeletal system morphogenesis
GO:0048873	homeostasis of number of cells within a tissue
GO:0050714	positive regulation of protein secretion
GO:0050830	defense response to Gram-positive bacterium
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051495	positive regulation of cytoskeleton organization
GO:0051592	response to calcium ion
GO:0051602	response to electrical stimulus
GO:0051649	establishment of localization in cell
GO:0051882	mitochondrial depolarization
GO:0051899	membrane depolarization
GO:0051901	positive regulation of mitochondrial depolarization
GO:0060079	excitatory postsynaptic potential
GO:0060907	positive regulation of macrophage cytokine production
GO:0070227	lymphocyte apoptotic process
GO:0070230	positive regulation of lymphocyte apoptotic process
GO:0070231	T cell apoptotic process
GO:0070234	positive regulation of T cell apoptotic process
GO:0070588	calcium ion transmembrane transport
GO:0071359	cellular response to dsRNA
GO:0071407	cellular response to organic cyclic compound
GO:0072593	reactive oxygen species metabolic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0098655	monoatomic cation transmembrane transport
GO:0099161	regulation of presynaptic dense core granule exocytosis
GO:1904172	positive regulation of bleb assembly
GO:1904669	ATP export

Biological Process

GO:0000165

MAPK cascade

GO:0000902

cell morphogenesis

GO:0001845

phagolysosome assembly

GO:0001913

T cell mediated cytotoxicity

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO:0002028

regulation of sodium ion transport

GO:0006509

membrane protein ectodomain proteolysis

GO:0006649

phospholipid transfer to membrane

GO:0006811

monoatomic ion transport

GO:0006812

monoatomic cation transport

GO:0006816

calcium ion transport

GO:0006884

cell volume homeostasis

GO:0006900

vesicle budding from membrane

GO:0006954

inflammatory response

GO:0007005

mitochondrion organization

GO:0007009

plasma membrane organization

GO:0007166

cell surface receptor signaling pathway

GO:0009306

protein secretion

GO:0009410

response to xenobiotic stimulus

GO:0009612

response to mechanical stimulus

GO:0009617

response to bacterium

GO:0010043

response to zinc ion

GO:0010467

gene expression

GO:0010524

positive regulation of calcium ion transport into cytosol

GO:0010628

positive regulation of gene expression

GO:0012501

programmed cell death

GO:0014047

glutamate secretion

GO:0014049

positive regulation of glutamate secretion

GO:0014051

gamma-aminobutyric acid secretion

GO:0014054

positive regulation of gamma-aminobutyric acid secretion

GO:0014070

response to organic cyclic compound

GO:0016079

synaptic vesicle exocytosis

GO:0016485

protein processing

GO:0017121

plasma membrane phospholipid scrambling

GO:0019228

neuronal action potential

GO:0019233

sensory perception of pain

GO:0030163

protein catabolic process

GO:0030501

positive regulation of bone mineralization

GO:0032060

bleb assembly

GO:0032308

positive regulation of prostaglandin secretion

GO:0032310

prostaglandin secretion

GO:0032496

response to lipopolysaccharide

GO:0032730

positive regulation of interleukin-1 alpha production

GO:0032731

positive regulation of interleukin-1 beta production

GO:0032755

positive regulation of interleukin-6 production

GO:0032963

collagen metabolic process

GO:0033198

response to ATP

GO:0034220

monoatomic ion transmembrane transport

GO:0034405

response to fluid shear stress

GO:0034767

positive regulation of monoatomic ion transmembrane transport

GO:0035590

purinergic nucleotide receptor signaling pathway

GO:0042098

T cell proliferation

GO:0043029

T cell homeostasis

GO:0043065

positive regulation of apoptotic process

GO:0043132

NAD transport

GO:0043409

negative regulation of MAPK cascade

GO:0043410

positive regulation of MAPK cascade

GO:0045332

phospholipid translocation

GO:0045778

positive regulation of ossification

GO:0045779

negative regulation of bone resorption

GO:0045794

negative regulation of cell volume

GO:0045821

positive regulation of glycolytic process

GO:0046513

ceramide biosynthetic process

GO:0046931

pore complex assembly

GO:0048705

skeletal system morphogenesis

GO:0048873

homeostasis of number of cells within a tissue

GO:0050714

positive regulation of protein secretion

GO:0050830

defense response to Gram-positive bacterium

GO:0051209

release of sequestered calcium ion into cytosol

GO:0051495

positive regulation of cytoskeleton organization

GO:0051592

response to calcium ion

GO:0051602

response to electrical stimulus

GO:0051649

establishment of localization in cell

GO:0051882

mitochondrial depolarization

GO:0051899

membrane depolarization

GO:0051901

positive regulation of mitochondrial depolarization

GO:0060079

excitatory postsynaptic potential

GO:0060907

positive regulation of macrophage cytokine production

GO:0070227

lymphocyte apoptotic process

GO:0070230

positive regulation of lymphocyte apoptotic process

GO:0070231

T cell apoptotic process

GO:0070234

positive regulation of T cell apoptotic process

GO:0070588

calcium ion transmembrane transport

GO:0071359

cellular response to dsRNA

GO:0071407

cellular response to organic cyclic compound

GO:0072593

reactive oxygen species metabolic process

GO:0097190

apoptotic signaling pathway

GO:0097191

extrinsic apoptotic signaling pathway

GO:0098655

monoatomic cation transmembrane transport

GO:0099161

regulation of presynaptic dense core granule exocytosis

GO:1904172

positive regulation of bleb assembly

GO:1904669

ATP export

	Cellular Component
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031594	neuromuscular junction
GO:0032059	bleb
GO:0032991	protein-containing complex
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0045202	synapse
GO:0098794	postsynapse

Cellular Component

nuclear envelope

cytoplasm

mitochondrion

plasma membrane

cell-cell junction