Structure of PDB 6u13 Chain A Binding Site BS03

Receptor Information

>6u13 Chain A (length=266) Species: 522373 (Stenotrophomonas maltophilia K279a) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EAPLPQLRAYTVDASWLQPMAPLQVADHTWQIGTEDLTALLVQTAEGAVL
LDGGMPQMAGHLLDNMKLRGVAPQDLRLILLSHAHADHAGPVAELKRRTG
AHVAANAETAVLLARGGSNDLHFGDGITYPPASADRIIMDGEVVTVGGIA
FTAHFMPGHTPGSTAWTWTDTRDGKPVRIAYADSLSAPGYQLKGNPRYPR
LIEDYKRSFATVRALPCDLLLTPHPGASNWNYAVGSKASAEALTCNAYAD
AAEKKFDAQLARETAG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6u13 Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6u13 Crystal Structure of the metallo-beta-lactamase L1 from Stenotrophomonas maltophilia in the complex with the hydrolyzed antibiotic moxalactam.
Resolution	1.52 Å
Binding residue (original residue number in PDB)	D109 H110 H246
Binding residue (residue number reindexed from 1)	D87 H88 H224
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H105 H107 D109 H110 H181 Y212 H246
Catalytic site (residue number reindexed from 1)	H83 H85 D87 H88 H159 Y190 H224
Enzyme Commision number	3.5.2.6: beta-lactamase.

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0008800	beta-lactamase activity

	Biological Process
GO:0017001	antibiotic catabolic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:6u13, PDBe:6u13, PDBj:6u13
PDBsum	6u13
PubMed
UniProt	B2FTM1

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