Structure of PDB 6su9 Chain A Binding Site BS03

Receptor Information

>6su9 Chain A (length=295) Species: 36329 (Plasmodium falciparum 3D7)

MKKENIISIQSQVFDGFCGNNIAAFVFRRRGHIPKILNTVQYYSKFKHSG
VELNSQEVDIILSEYNKDQENDSNIYFLTGYIKNAECVDMVTKNILELRR
KRKIHYFIENIINLNFLWVCDPVMGDNGRLYVDERVVESYKKAIEYVDII
TPNQYETELLCGIKINEEKDVIKCLDVLLHKGVKIVIITSVNYNFDKDHL
FLYVSFFNNKNKIVYFKYKILKIHFNCFGSGDLFSCLLLSFIVKQKGNIL
HIISKVLNIVQNVIKNSLTGLELNIIENQDIIASDDILIKEEPVF

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6su9 Chain A Residue 704

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6su9 Crystal structure of Plasmodium falciparum PdxK with ligands AMP-PNP and PL.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): F25 R28
• Binding residue (residue number reindexed from 1): F25 R28
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.35: pyridoxal kinase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008478 pyridoxal kinase activity
• GO:0016301 kinase activity
• GO:0046872 metal ion binding
• GO:0070280 pyridoxal binding
• GO:0070281 pyridoxamine binding
• GO:0070282 pyridoxine binding

Biological Process

• GO:0000304 response to singlet oxygen
• GO:0008614 pyridoxine metabolic process
• GO:0009443 pyridoxal 5'-phosphate salvage
• GO:0016310 phosphorylation
• GO:0042816 vitamin B6 metabolic process
• GO:0042819 vitamin B6 biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:6su9, PDBe:6su9, PDBj:6su9
• PDBsum: 6su9
• UniProt: C6KT01