Structure of PDB 6s3i Chain A Binding Site BS03

Receptor Information
>6s3i Chain A (length=434) Species: 56957 (Thermus oshimai) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSSEQQRAFLAVTQTPHPAHLITGPAGTGKTTLLYALQEFYKGRAVTLAP
TGTAALQARGQTVHSFFRFPARLLRYRHPEDIRPPGPHSPLRKAIEQMEV
LILDEVGMVRVDLLEAMDWALRKTRKRLEEPFGGVKVLLLGDTRQLEPVV
PGGEEALYIARTWGGPFFFQAHVWEEVALRVHRLWESQRQREDPLFAELL
KRLRQGDPQALETLNRAAVRPDGGEEPGTLILTPRRKEADALNLKRLEAL
PGKPLEYQAQVKGEFAETDFPTEAALTLKKGAQVILLRNDPLGEYFNGDL
GWVEDLEAEALAVRLKRNGRRVVIRPFVWEKIVYTYDSEREEIKPQVVGT
FRQVPVRLAWALTVHKAQGLTLDKVHLELGRGLFAHGQLYVALTRVRRLQ
DLSLSRPIAPTELLWRPEVEVFETRIQEGIWQKS
Ligand information
Ligand IDMF4
InChIInChI=1S/4FH.Mg/h4*1H;/q;;;;+2/p-4
InChIKeyXVYWAXYEHHUKQW-UHFFFAOYSA-J
SMILES
SoftwareSMILES
CACTVS 3.341F[Mg--](F)(F)F
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		F[Mg-2](F)(F)F
FormulaF4 Mg
NameTETRAFLUOROMAGNESATE(2-);
MAGNESIUMTETRAFLUORIDE
ChEMBL
DrugBank
ZINC
PDB chain6s3i Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6s3i Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.
Resolution2.455 Å
Binding residue
(original residue number in PDB)		E172 Q212 R256 G436 R462
Binding residue
(residue number reindexed from 1)		E105 Q145 R189 G369 R395
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000723 telomere maintenance
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6s3i, PDBe:6s3i, PDBj:6s3i
PDBsum6s3i
PubMed33784404
UniProtK7RJ88

[Back to BioLiP]