Structure of PDB 6r7w Chain A Binding Site BS03

Receptor Information
>6r7w Chain A (length=270) Species: 28112 (Tannerella forsythia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSSTILIPVVVHVVYNNSAQNISDAQIISQIQVLNEDFRRMNADQANTPS
AFANLAGNANIEFKLARRDPNGNTTNGITRTSTSTETFSMEMDNVKFSNL
GGNNAWNTRRYLNIWVCNLGDDLLGYAQFPFEFQTKPNTDGVVIHYKHFG
RDGSAESPYDKGRTATHEVGHWLDLRHIWGDDGGSCSGTDNIADTPNQGG
YNEGCPSFPKTDHCTNTSPGVMFMNYMDYTYDACMNLFTKGQVERMRSLF
DTQTGIRREMQIYANELTNP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6r7w Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r7w Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		D247 I249 T252
Binding residue
(residue number reindexed from 1)		D190 I192 T195
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:6r7w, PDBe:6r7w, PDBj:6r7w
PDBsum6r7w
PubMed31949901
UniProtG8ULV1

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