Structure of PDB 6p0e Chain A Binding Site BS03

Receptor Information
>6p0e Chain A (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFR
DIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSV
LAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCE
VPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFE
EAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIK
LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYA
FDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAE
FLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDL
VVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHH
QSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAAR
GLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB6p0e Two-tiered enforcement of high-fidelity DNA ligation.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		R305 T415 G416 S417 A418 T420 R451 G453 A455 Q457 S458 T639 T640 R641 K642 R643 R738 G767 R768 G769 K770 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870
Binding residue
(residue number reindexed from 1)		R46 T156 G157 S158 A159 T161 R192 G194 A196 Q198 S199 T380 T381 R382 K383 R384 R479 G508 R509 G510 K511 G517 K536 G538 S591 L592 S593 P594 Y596 S610 L611
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6p0e, PDBe:6p0e, PDBj:6p0e
PDBsum6p0e
PubMed31780661
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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