Structure of PDB 6o78 Chain A Binding Site BS03

Receptor Information
>6o78 Chain A (length=700) Species: 342948 (Thermococcus onnurineus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSENDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASPQA
SRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEEL
SKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRA
GCTAEDGRCRKEKRFLLIEGDFSGIQDFIYRVSTLKYLRARSAYLELIGW
DVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEWL
YREFESDLYLAIEWEPVSGREFGREGNLFAEARKRLKHKLTVRKLKRFGE
IKGLFEKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGEQILVKNTL
NPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGTRRLGVMKGD
VDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFGYIIGDVPSL
RDWPEEPDIVVVYAGGDAFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLS
VGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSRPLDGKHKLS
YEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIRELYVRDPN
DVRWAYLTAYLLSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLMAVR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6o78 Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6o78 Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D521 V522 D588
Binding residue
(residue number reindexed from 1)		D450 V451 D517
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6o78, PDBe:6o78, PDBj:6o78
PDBsum6o78
PubMed31326272
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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