Structure of PDB 6muj Chain A Binding Site BS03

Receptor Information

>6muj Chain A (length=289) Species: 100226 (Streptomyces coelicolor A3(2))

ARPRSTRGQVRLPGGEFAMGDAFGEGYPADGETPVHTVRLRPFHIDETAV
TNARFAAFVKATGHVTDAERFGSSAVFHLVVAAPDADVLGSAAGAPWWIN
VRGAHWRRPEGARSDITGRPNHPVVHVSWNDATAYARWAGKRLPTEAEWE
YAARGGLAGRRYAWGDELTPGGRWRCNIWQGRFPHVNTAEDGHLSTAPVK
SYRPNGHGLWNTAGNVWEWCSDWFSPTYYAESPTVDPHGPGTGAARVLRG
GSYLCHDSYCNRYRVAARSSNTPDSSSGNLGFRCANDAD

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 6muj Chain A Residue 505

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6muj Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2activation.
• Resolution: 2.249 Å
• Binding residue (original residue number in PDB): H95 H202
• Binding residue (residue number reindexed from 1): H78 H185
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.8.3.7: formylglycine-generating enzyme.

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0120147 formylglycine-generating oxidase activity
• GO:1903135 cupric ion binding

Biological Process

• GO:0018158 protein oxidation
• GO:0043687 post-translational protein modification

External links

• PDB: RCSB:6muj, PDBe:6muj, PDBj:6muj
• PDBsum: 6muj
• PubMed: 30824597
• UniProt: Q9F3C7|FGE_STRCO Formylglycine-generating enzyme (Gene Name=SCO7548)