Structure of PDB 6meq Chain A Binding Site BS03

Receptor Information

>6meq Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EPIRYAIPEELDRGSLVGNLAKDLGFGVGDLPTRNLRVIAEKKFFTVSPE
NGNLLVSDRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNP
PTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSL
IQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRV
IVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEIIYA
FINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAY
CKVQIDISDENDNAPEITLASESQHIQEDAELGTAVALIKTHDLDSGFNG
EILCQLKGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNP
PLSSSKTITLHILDAA

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6meq Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6meq Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	E223 E280 D309 E310 D312 D345
Binding residue (residue number reindexed from 1)	E223 E280 D309 E310 D312 D345
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6meq, PDBe:6meq, PDBj:6meq
PDBsum	6meq
PubMed	31431536
UniProt	Q9Y5G1\|PCDGF_HUMAN Protocadherin gamma-B3 (Gene Name=PCDHGB3)

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