Structure of PDB 6mdx Chain A Binding Site BS03

Receptor Information
>6mdx Chain A (length=183) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAG
ICSYEMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHG
PEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYYG
YVKRATNREPSAHDYWWAEHQKTCGGTYIKIKE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6mdx Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6mdx Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		C169 C173 H201 C205
Binding residue
(residue number reindexed from 1)		C138 C142 H170 C174
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006974 DNA damage response

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Molecular Function
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Biological Process
External links
PDB RCSB:6mdx, PDBe:6mdx, PDBj:6mdx
PDBsum6mdx
PubMed30893605
UniProtQ9H040|SPRTN_HUMAN DNA-dependent metalloprotease SPRTN (Gene Name=SPRTN)

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