Structure of PDB 6mdw Chain A Binding Site BS03

Receptor Information
>6mdw Chain A (length=185) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAG
ICSYEGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREG
HGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPY
YGYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6mdw Chain A Residue 805 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6mdw Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H111 H115 H130
Binding residue
(residue number reindexed from 1)		H82 H86 H101
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006974 DNA damage response

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Molecular Function
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Biological Process
External links
PDB RCSB:6mdw, PDBe:6mdw, PDBj:6mdw
PDBsum6mdw
PubMed30893605
UniProtQ9H040|SPRTN_HUMAN DNA-dependent metalloprotease SPRTN (Gene Name=SPRTN)

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