Structure of PDB 6m4m Chain A Binding Site BS03

Receptor Information
>6m4m Chain A (length=496) Species: 6396 (Eisenia fetida) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQYFGSYYCQPGRDVIVHLFEWKWTDIERECQWLADHNYCGVQVSPPNEH
RIVTDPPYPWWQRYQPVSYTMNSRSGSETQFRNMVTTCNNLGVYIYVDGV
LNHMTGGGSGTGSDGNSFDGDSLQYPGVPYGPNDFHGSDDCSTSDGEIHD
YNNPTEVRNCRLSGLRDLDGSANYVRDVEAEFANRLIGWGVAGFRLDACK
HMWPGDLEAILGRLNQLNTQWFPAGRNAYIYQQVIDLGGEAVKATEYTYL
GRVTEFKHGQNLGNVVRKNNGQRLANLVNFGEGWGQLSGFDALVFIDNHD
NQRGHGAGGFGTILTFFEANMYKIATAFELAWDYGHVRLMSSYNWPRNIV
NGVDTNDWVGPPTNGGGDTKDVECFNGEWICEHRWREMYNMVRFHNVAIG
NPVSNWWDNGFQAIAFGRGNRGFIFINNEDFAITQTLQTGLPGGEYCDVI
SCDNNRPPCGNSGGACRATVIVNGDGTATFDVPNGENPMIAIHVFL
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain6m4m Chain B Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m4m X-ray crystallographic structural studies of alpha-amylase I from Eisenia fetida.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		W76 Y80 H119 D213 Q249 H315 D316
Binding residue
(residue number reindexed from 1)		W60 Y64 H103 D197 Q233 H299 D300
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.1: alpha-amylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004556 alpha-amylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0043169 cation binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005615 extracellular space

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6m4m, PDBe:6m4m, PDBj:6m4m
PDBsum6m4m
PubMed32876059
UniProtA0A173N065

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