Structure of PDB 6lyk Chain A Binding Site BS03

Receptor Information
>6lyk Chain A (length=1293) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASGLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHF
ADLNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSK
ATDIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVF
SSLTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYL
QEAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKM
IKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHIL
MKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNL
RIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFR
TYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLG
GPAMNIGLGGGDLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHD
VGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYV
LAVAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPL
DVLLGKTPKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFL
VTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAP
VALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAG
LYDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVI
SAFARVEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGD
KPADVRDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGH
CGVQVDIAALGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCV
HYLGQALAGDRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCA
DQEHEAKANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNS
HVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGA
GEGWAKSILFNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSE
LWPRFVRNHSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVE
VRDDAHLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENG
RVTIMMPHPEAVFRTVANSWHPENWGEDSPWMRIFRNARKQLG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6lyk Chain A Residue 1621 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6lyk Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		D679 N722 D884
Binding residue
(residue number reindexed from 1)		D677 N720 D882
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.5.3: phosphoribosylformylglycinamidine synthase.
Gene Ontology
Molecular Function
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lyk, PDBe:6lyk, PDBj:6lyk
PDBsum6lyk
PubMed
UniProtP74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)

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