Structure of PDB 6lwb Chain A Binding Site BS03

Receptor Information
>6lwb Chain A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QPDLLELCHSVPKEVVQLGGRGYGEEDFAAFRAWLRCYGMPGMSSLQDRH
GRTIWFQGDPGPLAP
Ligand information
Receptor-Ligand Complex Structure
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PDB6lwb DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		K155 R159 R274
Binding residue
(residue number reindexed from 1)		K154 R158 R249
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwb, PDBe:6lwb, PDBj:6lwb
PDBsum6lwb
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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