Structure of PDB 6kle Chain A Binding Site BS03

Receptor Information
>6kle Chain A (length=1592) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTEQVESFNEIKHDVQVALAKMADVSLHEVKDFDPDVLP
PEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLKNLTTSSYVDEEYFM
CFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSISSNSGNLKFGLSYK
EQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFERAIC
DMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTPVDRSKIDLD
SVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFFHQTMQLNGQIPSHI
MSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYTSSDDQITL
IKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFVMGE
ETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVTRISK
RVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFHDDKET
SFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSEQEV
NRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQSKLSRQSSVASGFI
GFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICALKPKIIYCNNSLNKV
SQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNNQNFFWAVKPKVVRQ
IEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSGRLKFLDVC
IALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6kle Chain A Residue 2302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6kle Structural insight into arenavirus replication machinery.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		C470 H472
Binding residue
(residue number reindexed from 1)		C437 H439
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6kle, PDBe:6kle, PDBj:6kle
PDBsum6kle
PubMed32214249
UniProtQ6IVU0

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