Structure of PDB 6kc8 Chain A Binding Site BS03

Receptor Information
>6kc8 Chain A (length=1036) Species: 604162 (Neisseria meningitidis 8013) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SINYILGLDIGIASVGWAMVEIDEEENPIRLIDLGVRVFERAEVPGDSLA
MARRLARSVRRLTRRRAHRLLRTRRLLKREGVLQAANFDENGLIKSLPNT
PWQLRAAALDRKLTPLEWSAVLLHLIKHRGYLSQRKNETGDFRTPAELAL
NKFEKESGHIRNQRSDYSHTFSRKDLQAELILLFEKQKEFGNPHVSGGLK
EGIETLLMTQRPALSGDAVQKMLGHCTFEPAEPKAAKNTYTAERFIWLTK
LNNLRILEQGSERPLTDTERATLMDEPYRKSKLTYAQARKLLGLEDTAFF
KGLRYGKDNAEASTLMEMKAYHAISRALEKEGLKDKKSPLNLSPELQDEI
GTAFSLFKTDEDITGRLKDRIQPEILEALLKHISFDKFVQISLKALRRIV
PLMEQGKRYDEACAEIYGDHYGKKNTEEKIYLPPIPADEIRNPVVLRALS
QARKVINGVVRRYGSPARIHIETAREVGKSFKDRKEIEKRQEENRKDREK
AAAKFREYFSKDILKLRLYEQQHGKCLYSGKEINLGRLNEKGYVEIDHAL
PFSRTWDDSFNNKVLVLGSENQNKGNQTPYEYFNGKDNSREWQEFKARVE
TSRFPRSKKQRILLQDGFKERNLNDTRYVNRFLCQFVADRMRLTGKGKKR
VFASNGQITNLLRGFWGLRKVRAENDRHHALDAVVVACSTVAMQQKITRF
VRYKEMNAFDGKTIDTGEVLHQKTHFPQPWEFFAQEVMIRVFGKPDGKPE
FEEADTLEKLRTLLAEKLSSRPEAVHEYVTPLFVSRAPNRKMSGQGHMET
VKSAKRLDEGVSVLRVPLTQLKLKDLEKMVNREREPKLYEALKARLEAHK
DDPAKAFAEPFYKYDKAGNRTQQVKAVRVEQVQKTGVWVRNHNGIADNAT
MVRVDVFEKGDKYYLVPIYSWQVAKGILPDRAVVQGKDEEDWQLIDDSFN
FKFSLHPNDLVEVITKKARMFGYFASCHRGTGNINIRIHDLDHKIGKNGI
LEGIGVKTALSFQKYQIDELGKEIRPCRLKKRPPVR
Ligand information
Receptor-Ligand Complex Structure
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PDB6kc8 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		N944 T946 M947 Y965 H1024 R1025
Binding residue
(residue number reindexed from 1)		N898 T900 M901 Y919 H978 R979
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6kc8, PDBe:6kc8, PDBj:6kc8
PDBsum6kc8
PubMed31668930
UniProtC9X1G5|CAS9_NEIM8 CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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