Structure of PDB 6k0g Chain A Binding Site BS03

Receptor Information
>6k0g Chain A (length=335) Species: 565042 (Bifidobacterium longum subsp. longum JCM 1217) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTVLVTGGAGFIATHTDIELLNKGYDVISVDNYGNSSPVALERVEQITGK
PVKRYDGDVRDEALMERVFAENNIDWVIHFAGLKAVGESVAKPIEYYDNN
LYSTLVLLKVMKKHNVKKIIFSSSATVYGTPKELPITEETPTGGTTNPYG
TSKLFQEQILRDVHVADPSWTIVLLRYFNPVGAHESGLLGEDPKGIPANL
TPYVAKVAVGELKEVQVYGDDYDTPDGTGVRDYIHVVDLAKGHVAVIDHI
DKEGVFVYNLGTGHGYSVLEVIKAYEKAAGHPIPYAIKPRRPGDIAACYA
DASKAEKELGWKAELTIDDMAASSLNWQTKNPNGF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6k0g Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6k0g Structural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		E67 H115
Binding residue
(residue number reindexed from 1)		E66 H114
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S125 A126 T127 Y150 K154
Catalytic site (residue number reindexed from 1) S124 A125 T126 Y149 K153
Enzyme Commision number 5.1.3.2: UDP-glucose 4-epimerase.
Gene Ontology
Molecular Function
GO:0003978 UDP-glucose 4-epimerase activity
GO:0016853 isomerase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006012 galactose metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k0g, PDBe:6k0g, PDBj:6k0g
PDBsum6k0g
PubMed31366978
UniProtE8MF10|GALE_BIFL2 UDP-glucose 4-epimerase (Gene Name=lnpD)

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