Structure of PDB 6jt2 Chain A Binding Site BS03

Receptor Information
>6jt2 Chain A (length=506) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKFEKTIAEQAVAAGVP
VEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQASILCL
LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLYLLYSVHSLVIPTS
LFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDKPNFEEYFEILTPKINQ
TFSGIMTMLNMQFVVRVRRVMDLKGQMIYIVESSAILFLGSPCVLYLSDI
PIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDL
LCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVI
TMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA
VKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTL
ANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGI
CHFLDA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6jt2 Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6jt2 Structural insights into the mechanism of human soluble guanylate cyclase.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		D486 D530
Binding residue
(residue number reindexed from 1)		D333 D377
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D486 I487 D530
Catalytic site (residue number reindexed from 1) D333 I334 D377
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Gene Ontology
Molecular Function
GO:0004383 guanylate cyclase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0020037 heme binding
GO:0038023 signaling receptor activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009190 cyclic nucleotide biosynthetic process
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0019934 cGMP-mediated signaling
GO:0035556 intracellular signal transduction
GO:0038060 nitric oxide-cGMP-mediated signaling
GO:0060087 relaxation of vascular associated smooth muscle
GO:0070482 response to oxygen levels
GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008074 guanylate cyclase complex, soluble
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6jt2, PDBe:6jt2, PDBj:6jt2
PDBsum6jt2
PubMed31514202
UniProtQ02108|GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (Gene Name=GUCY1A1)

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