Structure of PDB 6jk8 Chain A Binding Site BS03

Receptor Information
>6jk8 Chain A (length=823) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISRSYRFPKLTVITEYL
LLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRN
ITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPCE
KTTINNEYNYRCWTTNRCQKMCPSTCACTENNECCHPECLGSCSAPDNDT
ACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGF
VIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTS
AQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHAL
VSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKM
YFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFT
STTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGS
NSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRG
AKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIV
RWQRQPQDGYLYRHNYCSKDKIPIRKYAGPCCACPKTEAEKQAEKEEAEY
RKVFENFLHNSIFVPRPYPFFESRVDNKERTVISNLRPFTLYRIDIHSCN
HEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPEN
PNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQA
TSLSGNGSWTDPVFFYVQAKTGY
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain6jk8 Chain F Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6jk8 Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		T498 T500
Binding residue
(residue number reindexed from 1)		T452 T454
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jk8, PDBe:6jk8, PDBj:6jk8
PDBsum6jk8
PubMed32275863
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

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