Structure of PDB 6ji2 Chain A Binding Site BS03

Receptor Information

>6ji2 Chain A (length=432) Species: 272557 (Aeropyrum pernix K1)

KPHMNLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESF
KFAWILDKMKEERERGITIDLTFMKFETKKYVFTIIDAPGHRDFVKNMIT
GASQADAAILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQIIVAVNK
MDAPDVNYDQKRYEFVVSVLKKFMKGLGYQVDKIPFIPVSAWKGDNLIER
SPNMPWYNGPTLVEALDQLQPPAKPVDKPLRIPVQNVYSIPGAGTVPVGR
VETGVLRVGDKVVFMPPGVVGEVRSIEMHYQQLQQAEPGDNIGFAVRGVS
KSDIKRGDVAGHLDKPPTVAEEFEARIFVIWHPSAITVGYTPVIHVHTAS
VSSRIIEIKAKLDPKTGQVVEQNPQFLKAGDAAIVRFKPVKPLVVEKFSE
IPQLGRFAMRDMNRTVGIGIVTDVKPAKVDIK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6ji2 Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ji2 Switch of the interactions between the ribosomal stalk and EF1A in the GTP- and GDP-bound conformations.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): S20 T71 D90
• Binding residue (residue number reindexed from 1): S17 T68 D87
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D16 K19 S20 T71 H94
• Catalytic site (residue number reindexed from 1): D13 K16 S17 T68 H91

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6ji2, PDBe:6ji2, PDBj:6ji2
• PDBsum: 6ji2
• PubMed: 31611569
• UniProt: Q9YAV0|EF1A_AERPE Elongation factor 1-alpha (Gene Name=tuf)