Structure of PDB 6iaf Chain A Binding Site BS03

Receptor Information

>6iaf Chain A (length=172) Species: 8400 (Aquarana catesbeiana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VSQVRQNYHSDCEAAVNRMLNLELYASYTYSSMYAFFDRDDVALHNVAEF
FKENSHEEREHAEKFMKYQNKRGGRVVLQDIKKPERDEWGNTLEAMQAAL
QLEKTVNQALLDLHKLATDKVDPHLCDFLESEYLEEQVKDIKRIGDFITN
LKRLGLPENGMGEYLFDKHSVK

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

6iaf Chain A Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6iaf Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.
Resolution	1.35 Å
Binding residue (original residue number in PDB)	E57 E136 D140
Binding residue (residue number reindexed from 1)	E57 E136 D140
Annotation score	5

Enzymatic activity

Enzyme Commision number

1.16.3.1: ferroxidase.

Gene Ontology

	Molecular Function
GO:0004322	ferroxidase activity
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006826	iron ion transport
GO:0006879	intracellular iron ion homeostasis
GO:0006880	intracellular sequestering of iron ion

	Cellular Component
GO:0005737	cytoplasm

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External links

PDB	RCSB:6iaf, PDBe:6iaf, PDBj:6iaf
PDBsum	6iaf
PubMed	31075719
UniProt	P07798\|FRI2_AQUCT Ferritin, middle subunit

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