Structure of PDB 6h61 Chain A Binding Site BS03

Receptor Information
>6h61 Chain A (length=660) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASES
GKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKS
YDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNN
IMRRYLKQKLRNNDLKKQNAIPLPQILGLTASPGVGAAKKQSEAEKHILN
ICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIANPFKEKLLEIMASIQT
YCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQI
NDTIRMIDAYSHLETFYTDEKEKKFAVLNLDETDEFLMNLFFDNKKMLKK
LAENPKEKLIKLRNTILEQFTRSESSRGIIFTKTRQSTYALSQWIMENAK
VGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAELDI
KECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGVTEREIVNDFR
EKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNP
SLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKTNGEI
ICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRF
PDLDYSEYCL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6h61 Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6h61 Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution4.02 Å
Binding residue
(original residue number in PDB)		C910 C962 C964
Binding residue
(residue number reindexed from 1)		C560 C602 C604
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0038187 pattern recognition receptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0002376 immune system process
GO:0009615 response to virus
GO:0016925 protein sumoylation
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0039530 MDA-5 signaling pathway
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0060337 type I interferon-mediated signaling pathway
GO:0060760 positive regulation of response to cytokine stimulus
GO:0071360 cellular response to exogenous dsRNA
GO:0098586 cellular response to virus
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h61, PDBe:6h61, PDBj:6h61
PDBsum6h61
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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