Structure of PDB 6gx9 Chain A Binding Site BS03

Receptor Information
>6gx9 Chain A (length=912) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLL
QIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLS
PVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLP
EEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKV
FRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCS
ALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTE
LCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGE
HLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRM
RVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSV
DPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDP
VLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSF
LLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQSSD
PTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNR
IVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSIL
VDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLAT
RFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGV
ANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVL
WEIMQVDRPTFCRWLENSLKGLPKETVTVTHKQLTDFHKQVTSAEECKQV
CWALRDFTRLFR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6gx9 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6gx9 Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E812 E813
Binding residue
(residue number reindexed from 1)		E805 E806
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gx9, PDBe:6gx9, PDBj:6gx9
PDBsum6gx9
PubMed30916345
UniProtQ9Y5L0|TNPO3_HUMAN Transportin-3 (Gene Name=TNPO3)

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