Structure of PDB 6grb Chain A Binding Site BS03

Receptor Information

>6grb Chain A (length=398) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GIKGIYKEIGSGERISLCKLAIDHLEQHNRPLRLAIDMAIWQFQIQAARG
GSNPAIRTLFYRFVRLLSLGIHPIFVFDGPNKSTAMAKRLIRLFGFTAHD
APGEAEAECAYLEQQGIVDAVLSEDVDTIMFGSRVTLRDWSSEGGPPTHV
TLHDAKKIAEGPSGLDREGMVLVALMSGGDYLPDGIPGCGIKVACQAAKA
GFGKELCRIKRAITEWKQRLLHELRTNESGFFRTKHKALEIPENFPNMEV
LRYYTHPVVSSPATIERLRQEFPPSSTVDIAGLREFTRETFDWTFRPGAI
KLIKVLAPGLLVQRCLDRKEESTLVKGISMRREHFSTDATPELRVSFIPA
ELVGLDPGQEPEVKPFDPWQPDLAWVPETILKLGVPVTVEDWEEGQRS

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6grb Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6grb A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	D141 D143
Binding residue (residue number reindexed from 1)	D125 D127
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004518	nuclease activity
GO:0008821	crossover junction DNA endonuclease activity

View graph for
Molecular Function

External links

PDB	RCSB:6grb, PDBe:6grb, PDBj:6grb
PDBsum	6grb
PubMed	30247722
UniProt	G0RYN2

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