Structure of PDB 6gpg Chain A Binding Site BS03

Receptor Information
>6gpg Chain A (length=651) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPFKPRNYQLELALPAMKGKNTIICAPTGFGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASV
IATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKR
ICKDLNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHL
RKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQ
ELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKN
WIEGNPKLSFLKPGILTGDHNILIATSVADEGIDIAQCNLVILYEYVGNV
IKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTW
DEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTA
DVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSH
DWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPA
E
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6gpg Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6gpg Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
Resolution2.894 Å
Binding residue
(original residue number in PDB)		C810 C813 C864 W873
Binding residue
(residue number reindexed from 1)		C539 C542 C593 W602
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6gpg, PDBe:6gpg, PDBj:6gpg
PDBsum6gpg
PubMed30047865
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

[Back to BioLiP]