Structure of PDB 6go5 Chain A Binding Site BS03

Receptor Information
>6go5 Chain A (length=343) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSVL
KSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYKS
FKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYED
LVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFLI
TSPEAEEQQLLHKVTDFWKQQGLLLYHQYHRSHSSTMDVFERSFCILKLD
HGRVHQEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHE
RKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA
Ligand information
Receptor-Ligand Complex Structure
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PDB6go5 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		Q152 G186 S187 A190 P215 C216 G218 K220 V221
Binding residue
(residue number reindexed from 1)		Q4 G38 S39 A42 P67 C68 G70 K72 V73
Enzymatic activity
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6go5, PDBe:6go5, PDBj:6go5
PDBsum6go5
PubMed31138645
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt);
Q9JIW4|DPOLM_MOUSE DNA-directed DNA/RNA polymerase mu (Gene Name=Polm)

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