Structure of PDB 6g1s Chain A Binding Site BS03

Receptor Information
>6g1s Chain A (length=645) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGK
VIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYD
VIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIM
RRYLKQKLRNNDLKAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANL
DAFTIKTVKENLGQLKHQIKEPCKKFVIANPFKEKLLEIMASIQTYCQKS
PMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIR
MIDAYSHLETFYTDEKEKKFAVLNDETDEFLMNLFFDNKKMLKKLAENPK
EKLIKLRNTILEQFTRSSRGIIFTKTRQSTYALSQWIMENAKVKAHHLIG
AGHSSEVKPMTQTEQKEVISKFRTINLLIATTVAGLDIKECNIVIRYGLV
TNEIAMVQARGRARADESTYVLVTSSGVTEREIVNDFREKMMYKAINRVQ
NMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSM
LVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKTNGEIICKCGQAWGTMM
VHKGLDLPCLKIRNFVVNFSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6g1s Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g1s Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution3.93 Å
Binding residue
(original residue number in PDB)		C910 C964
Binding residue
(residue number reindexed from 1)		C548 C592
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6g1s, PDBe:6g1s, PDBj:6g1s
PDBsum6g1s
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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