Structure of PDB 6g19 Chain A Binding Site BS03

Receptor Information
>6g19 Chain A (length=682) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASE
SGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVK
SYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYN
NIMRRYLKQKLRNNDLKKAIPLPQILGLTASPGVGAAKKQSEAEKHILNI
CANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMA
SIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNE
ALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNKLDETDEFLMNLFFDNK
KMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYAL
SQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEIN
LLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVT
SSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEK
KMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPE
FKGLYIVRENKALQKYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFV
VNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6g19 Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g19 Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution3.68 Å
Binding residue
(original residue number in PDB)		C907 C962 C964
Binding residue
(residue number reindexed from 1)		C573 C624 C626
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6g19, PDBe:6g19, PDBj:6g19
PDBsum6g19
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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