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Receptor Information

>6fhi Chain A (length=709) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMGS
GSGENLYFQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6fhi Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
Resolution	2.8 Å
Binding residue (original residue number in PDB)	A287 M288 K289 L290 S291 T313 L412 F440 E444 Q447 R449 M543 I545 R546 T547 K554 F607 K630 R633
Binding residue (residue number reindexed from 1)	A272 M273 K274 L275 S276 T298 L397 F425 E429 Q432 R434 M528 I530 R531 T532 K539 F592 K615 R618

Enzyme Commision number

	Molecular Function
GO:0003723	RNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0039694	viral RNA genome replication
GO:0075523	viral translational frameshifting

PDB	RCSB:6fhi, PDBe:6fhi, PDBj:6fhi
PDBsum	6fhi
PubMed
UniProt	H6QM92

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Structure of PDB 6fhi Chain A Binding Site BS03