Structure of PDB 6dt1 Chain A Binding Site BS03

Receptor Information
>6dt1 Chain A (length=464) Species: 10665 (Tequatrovirus T4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMILKILNEIASIGSTKQKQAILEKNKDNELLKRVYRLTYSRGLQYYIKK
WPKPGIATQSFGMLTLTDMLDFIEFTLATRKLTGNAAIEELTGYITDGKK
DDVEVLRRVMMRDLECGASVSIANKVWPGLIPEQPQMLASSYDEKGINKN
IKFPAFAQLKADGARCFAEVRGDELDDVRLLSRAGNEYLGLDLLKEELIK
MTAEARQIHPEGVLIDGELVYHEQAEVAESRTASNGIANKSLKGTISEKE
AQCMKFQVWDYVPLVEIYSLPAFRLKYDVRFSKLEQMTSGYDKVILIENQ
VVNNLDEAKVIYKKYIDQGLEGIILKNIDGLWENARSKNLYKFKEVIDVD
LKIVGIYPHRKDPTKAGGFILESECGKIKVNAGSGLKDKAGVKSHELDRT
RIMENQNYYIGKILECECNGWLKSDGRTDYVKLFLPIAIRLREDKTKANT
FEDVFGDFHEVTGL
Ligand information
Receptor-Ligand Complex Structure
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PDB6dt1 T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		R79 T82 N84 G116 S118 S120 I121 K124 T255 G259 N262 K263 T268 K361 Y380 H382 R383 K384 G390 N404 G406 S407 R422 D448 R450 K455 L456 F457
Binding residue
(residue number reindexed from 1)		R80 T83 N85 G117 S119 S121 I122 K125 T232 G236 N239 K240 T245 K338 Y357 H359 R360 K361 G367 N381 G383 S384 R399 D425 R427 K432 L433 F434
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6dt1, PDBe:6dt1, PDBj:6dt1
PDBsum6dt1
PubMed30169742
UniProtP00970|DNLI_BPT4 DNA ligase (Gene Name=30)

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