Structure of PDB 6cx0 Chain A Binding Site BS03

Receptor Information
>6cx0 Chain A (length=619) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKAAALVDLAEDGIGLPVEILDQSSESARYYFIFTRLDLIWSLNYFALLF
LNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLV
HTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLFRIAPYVRVII
FILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMFEDTQQG
LTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVY
FVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDK
NQCIKLFEQLTNYRTLPKISKEEFGLIFDNKDEFADLCQAIALRFQKEEV
PSLQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLDIEESS
AQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVI
GETATFITPFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPS
LMPYLGTIFCVLCIYCSIGVQVFGGLGNKKLFETELAEDDYLLFNFNDYP
NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLV
VAFVLEAFFTELDLEEEEK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6cx0 Chain A Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cx0 Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Resolution3.501 Å
Binding residue
(original residue number in PDB)		D335 D337 E341 I342 D343 Q346
Binding residue
(residue number reindexed from 1)		D291 D293 E297 I298 D299 Q302
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0009845 seed germination
GO:0010119 regulation of stomatal movement
GO:0019722 calcium-mediated signaling
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0080141 regulation of jasmonic acid biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cx0, PDBe:6cx0, PDBj:6cx0
PDBsum6cx0
PubMed30190435
UniProtQ94KI8|TPC1_ARATH Two pore calcium channel protein 1 (Gene Name=TPC1)

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