Structure of PDB 6cv7 Chain A Binding Site BS03

Receptor Information
>6cv7 Chain A (length=365) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPT
IELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVN
KKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG
DNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNY
EDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP
NTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGI
LYSILVGTPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNG
HPLPAFASLHIEILD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6cv7 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cv7 Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture.
Resolution1.692 Å
Binding residue
(original residue number in PDB)		N120 N122 D157 D159 N163 D215
Binding residue
(residue number reindexed from 1)		N119 N121 D156 D158 N162 D214
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007605 sensory perception of sound
GO:0048839 inner ear development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032420 stereocilium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cv7, PDBe:6cv7, PDBj:6cv7
PDBsum6cv7
PubMed30057206
UniProtQ99PJ1|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)

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