Structure of PDB 6cst Chain A Binding Site BS03

Receptor Information
>6cst Chain A (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIE
NMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAV
EMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLI
IVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWP
EDKRRYFIKNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKV
CSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIIT
CTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTF
SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRAS
TVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6cst 2.0 angstrom resolution crystal structure of human pol kappa reveals a new catalytic function of N-clasp in DNA replication.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		I165 I166
Binding residue
(residue number reindexed from 1)		I150 I151
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cst, PDBe:6cst, PDBj:6cst
PDBsum6cst
PubMed30310122
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

[Back to BioLiP]