Structure of PDB 6bz3 Chain A Binding Site BS03

Receptor Information
>6bz3 Chain A (length=125) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDET
IPALPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQML
TAAHALAVDAKNLLDVIDQARLKML
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6bz3 Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6bz3 The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction.
Resolution2.497 Å
Binding residue
(original residue number in PDB)		S940 K941 Q943
Binding residue
(residue number reindexed from 1)		S19 K20 Q22
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004713 protein tyrosine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly
Cellular Component
GO:0005925 focal adhesion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bz3, PDBe:6bz3, PDBj:6bz3
PDBsum6bz3
PubMed29479476
UniProtP34152|FAK1_MOUSE Focal adhesion kinase 1 (Gene Name=Ptk2)

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