Structure of PDB 6bkg Chain A Binding Site BS03

Receptor Information
>6bkg Chain A (length=600) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKN
DVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALK
LLNYRTPTGDAGDFAMIAYFVLKPRCQKGSLTIQQVNDLLDSIASNNSAK
RKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAA
ELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKD
MKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLT
PFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMDLQTCYCV
FDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVID
ALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILI
VGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELY
DLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVP
SDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6bkg Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Resolution2.402 Å
Binding residue
(original residue number in PDB)		K451 Y454 G509 C510 T511 F578 R580
Binding residue
(residue number reindexed from 1)		K435 Y438 G493 C494 T495 F562 R564
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bkg, PDBe:6bkg, PDBj:6bkg
PDBsum6bkg
PubMed29980672
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

[Back to BioLiP]